| Autor: |
Wan Ahmad, Wan Azman, SK Abdul Kader, Muhamad Ali S, Ross, Noel Thomas, Ramli, Ahmad Wazi, Ghazi, Azmee Mohd, Che Hassan, Hamat Hamdi, Lee, Chuey Yan, Fegade, Mayuresh, Zainal Abidin, Hafisyatul Aiza, Karthikesan, Dharmaraj, Mohd Amin, Nor Hanim, Ong, Tiong Kiam, Mahendran, Kauthaman A, Muthusamy, Tamil Selvan, ghapar, drkahar |
| Zdroj: |
Circulation (Ovid); November 2021, Vol. 144 Issue: Supplement 1 pA12125-A12125, 1p |
| Abstrakt: |
Introduction:There is scarcity of big data on Heart Failure (HF) in the Asean region in the current era of guideline directed medical therapy (GDMT). Malaysia Heart Failure (MYHF) Registry was set up in 2019 to advance fundamental understanding of the burden, morbidity and mortality among Malaysian patients with HFObjective:This analysis is to determine baseline characteristics, diagnostic work up and treatment pattern of patients admitted with the diagnosis of HF to address the unmet and growing clinical needs of HF patients in Malaysia.Methods:The first ever National HF Registry is planned as a prospective, observational study of HF patients (NYHA II-IV) across 18 tertiary care centers in Malaysia over a period of 3 years starting in 2019. This Registry recruited all patients admitted with a clinical diagnosis of HF by the attending physician with a minimum hospital stay of 24 hours for stabilisation prior to discharge. Primary endpoint is all cause mortality and hospital readmission for acute decompensated heart failure (ADHF) at one year. This paper summarizes baseline and clinical characteristics of patients along with treatment pattern and outcomes of index hospitalization.Results:We evaluated 2673 patients with mean age of 60 years (SD 13.8). De novo HF constituted one third of hospitalizations. Mean left ventricular ejection fraction (LVEF) was 36.4% (SD 15.3) stratified into 65% of HFrEF (LVEF ≤ 40%), 21% of HFpEF (LVEF ≥ 50%); and 11% of HFmrEF (LVEF 41-49%). Prior to index HF hospitalization, proportion of patients on BB, ACEi, ARBs, ARNI, MRA and ivabradine were 57%, 32%, 8%, 6%, 24% & 6% respectively changing to 79%, 36%, 8%, 15%, 43% & 12% at discharge of the patient. Mean length of hospital stay was 7.3 days (SD 8.9). In-hospital mortality was 3% attributed largely to cardiac causes (68%).Conclusions:The registry identifies at-risk patient populations with HF and highlights lesser prevalence of HFpEF compared to other HF registries. The analysis shows increased usage of GDMT post HF hospitalization event remarkably for BB, MRA, ivabradine and ARNI indicating hospitalization as a key opportunity to initiate GDMT in HF patients. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
