| Autor: |
Chamley, Rebecca R, Collins, Jonathan, Pierce, Kayleigh, Watson, William, Green, Peregrine, O'Brien, David, Barker-Davies, Robert, Neubauer, Stefan, Bennett, Alexander, Nicol, Ed D, Rider, Oliver J, Holdsworth, David A |
| Zdroj: |
Circulation (Ovid); November 2021, Vol. 144 Issue: Supplement 1 pA13757-A13757, 1p |
| Abstrakt: |
Background:COVID-19 has documented multisystem effects. Whether clinically significant cardiac involvement is related to severity of disease in a working age military population remains unknown, but has implications for occupational grading and ability to deploy.Aims:To determine in the military population 1) whether prior SARS-CoV-2 infection causes clinically significant cardiac disease and 2) whether changes are related to disease severity.Methods:105 military personnel were recruited, 85 with prior SARS-CoV-2 infection (39±10 years, 87% male; 50 mild (community), 35 severe (hospitalized) and 20 healthy volunteers (mean age 39 ±8.4 years, 90% male) underwent comprehensive cardiopulmonary investigations including; cardiopulmonary exercise test, exercise echocardiography, cardiac MRI and 31P-MR spectroscopy (rest and dobutamine stress).Results:Prior SARS-CoV-2 infection was related to lower VO2max (110±18.2 vs 133±6.7% predicted, p<0.05), anaerobic threshold (45±10 vs 56±14% of peak VO2, p<0.05), VO2/HR (102±21 vs 128±24% predicted, p<0.05) and VE/VCO2 slope (28.3±5.0 vs 25.8±2.7, p<0.05) and an increase in average E/e’ change from rest to exercise stress (+1.49±2.4 vs -0.16±3.6, p<0.05). Whilst resting myocardial energetics were similar, prior SARS-CoV-2 infection was associated with a fall in PCr/ATP during stress (by 8%, p=<0.01) which was not seen in healthy controls. When groups were ordered normal> mild> severe disease, RVEDVi, RV stroke volume, VO2peak, VO2pulse and VE/VCO2slope were reduced (Jonckheere-Terpstra, all p<0.05).Conclusion:In a young military population, prior SARS-CoV-2 infection is associated with subclinical cardiovascular changes including; lower right ventricular volumes, reduced markers of exercise capacity and reduced myocardial energetics during stress. |
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