| Abstrakt: |
Background:With an increasing number of states legalizing therapeutic and recreational marijuana and being considered comparatively safer substance with few negative side effects, the use of marijuana is expected to surge. We aimed to examine the risk of young-onset stroke (YOS) (18-44 years) among marijuana users from a national survey.Methods:The study analyzed pooled data from the Behavioral Risk Factor Surveillance System (BRFSS) (2016-17), a nationally representative cross-sectional survey collected by the CDC. Baseline sociodemographic were compared and multivariable logistic regression models with state fixed effects were used to examine the association of recent marijuana use (in last 30 days) with YOS adjusting for demographics, risk behavior, and relevant comorbidities.Results:Of 43,860 (weighted 35.5 million; 63.3% male) survey participants, 13.6 % reported using marijuana in the last 30 days (Table 1A). Compared to non-users, marijuana users were often younger, non-Hispanic white or black and had some college education. Marijuana users more frequently reported routine physical activity (81.8% vs. 77.5%, p<0.05), heavy drinking (16.8% vs. 4.9%, p<0.05), current cigarette smoking (37.9% vs. 15%, p<0.05), and lower prevalence of diabetes (2.0% vs. 4.9%, p<0.05) compared to non-users. Furthermore, marijuana users had higher odds of YOS on unadjusted analysis (OR 1.59 [0.99-2.56], p<0.1), which further increased after controlling individual characteristics, risk behaviors, relevant comorbidities, and state fixed effects. (Adjusted OR 2.75 [1.30-5.80], p<0.01) (Table 1B).Conclusions:Marijuana use among individuals aged 18-44 yrs is associated with significantly higher odds of YOS compared to non-users. |
