| Autor: |
Rashid, Mohamad, Davoren, Katherine, Moy, Norma B, Nafeh, Fida, Elashoff, Robert, Kim, Chulkyu, Kim, Elizabeth, Cheng, Susan, Rader, Florian |
| Zdroj: |
Circulation (Ovid); November 2019, Vol. 140 Issue: Supplement 1 pA14890-A14890, 1p |
| Abstrakt: |
Background:Electronic (e-) cigarettes are marketed as a safer alternative to tobacco cigarettes. While providing a lower level of nicotine, the e-cigarette delivery method involves creating an aerosolized bolus of poorly-characterized ultrafine particles that may confer adverse cardiovascular effects. Thus, we investigated whether e-cigarette use may alter coronary endothelial function.Methods:We studied healthy adults (age 28?1 yrs): non-smoking controls (n=10) e-cigarette users (n=17), and cigarette smokers (n=16). After overnight abstinence, participants underwent acute exposure to 1 use (15 puffs in 7 min) of a popular e-cigarette (3.7V battery,18 mg nicotine) and 1 cigarette (Camel Filtered, ?0.8 mg of nicotine). We then used myocardial contrast echo to measure acute increases in myocardial blood flow (MBF) induced by ischemic rhythmic handgrip, which causes sympathetically-mediated increases in myocardial work and oxygen demand (MVO2) and, in turn, shear stress, NO production, and coronary endothelial-dependent vasodilation.Results:In non-smoking controls, handgrip increased MBF by +72?16% (p<0.03 vs. rest) in proportion to increased MVO2, indicating normal endothelial function (Figure). Despite similar increases in MVO2, MBF tended to decrease when handgrip was performed after acute e-cigarette use (?MBF=-32?8%) or cigarette smoking (?MBF=-33?7%), indicating comparable acute smoking induced endothelial dysfunction. Surprisingly, 12 hours after acute exposure, endothelial function remained impaired after abstinence from e-cigarettes (?MBF -14?6%) but was partially restored after abstinence from cigarette (?MBF +33?13%).Conclusion:In young healthy adults, myocardial contrast echocardiography demonstrated that e-cigarette use leads to significant impairment in coronary microvascular endothelial function that is similar in magnitude but more persistent than that seen with conventional tobacco cigarette use. |
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