Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

Autor: Janusz, M. J., Hookfin, E. B., Brown, K. K., Hsieh, L. C., Heitmeyer, S. A., Taiwo, Y. O., Natchus, M. G., Pikul, S., Almstead, N. G., Peng, B. De S. X., Baker, T. R., Patel, V.
Zdroj: Inflammation Research; February 2006, Vol. 55 Issue: 2 p60-65, 6p
Abstrakt: Objective and Design:Hydroxamic-and carboxylic- acid based matrix metalloproteinase inhibitors (MMPIs) were compared for their potency against various MMPs, pharmacodynamic properties and in vivo efficacy in a model of cartilage degeneration.
Databáze: Supplemental Index
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