| Autor: |
Rossiter, S., Woo, C. K., Hartzoulakis, B., Wishart, G., Stanyer, L., Labadie, J. W., Selwood, D. L. |
| Zdroj: |
Journal of Combinatorial Chemistry; May 2004, Vol. 6 Issue: 3 p385-390, 6p |
| Abstrakt: |
A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. Cupric acetate-mediated N-arylation with aryl boronic acids proceeded regioselectively to form the N-2-substituted derivatives. The presence of the 3-dimethylaminopropyloxy group was found to completely control the regioselectivity of the arylation. Presence of a dimethylaminoethyloxy or dimethylaminobutyloxy group gave a lesser degree of regioselectivity. The scope of the method as applied to library synthesis is discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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