Helicterins A – F, Six New Dimeric (7.5',8.2')-Neolignans from the Indonesian Medicinal Plant Helicteres isora

Autor: Tezuka, Yasuhiro, Terazono, Masataka, Kusumoto, Tomoco I., Hatanaka, Yasumaru, Kadota, Shigetoshi, Hattori, Masao, Namba, Tsuneo, Kikuchi, Tohru, Tanaka, Ken, Supriyatna, Sutardjo
Zdroj: Helvetica Chimica Acta; November 8, 2000, Vol. 83 Issue: 11 p2908-2919, 12p
Abstrakt: During a chemical study of Indonesian medicinal plants, we examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines. From a H2O extract of the fruits, we isolated six new neolignans, the helicterins A – F (1 – 6), and elucidated their structures by spectral analyses. Helicterins A – F (1 – 6) are dimeric (7.5',8.2')-neolignans with a bicyclo[2.2.2]octene C-framework, and showed mild inhibitory activity against reverse transcriptase from avian myeloblastosis virus.
Databáze: Supplemental Index