| Autor: |
van der Ploeg, Kattria, Kirosingh, Adam S., Mori, Diego A.M., Chakraborty, Saborni, Hu, Zicheng, Sievers, Benjamin L., Jacobson, Karen B., Bonilla, Hector, Parsonnet, Julie, Andrews, Jason R., Press, Kathleen D., Ty, Maureen C., Ruiz-Betancourt, Daniel R., Parte, Lauren de la, Tan, Gene S., Blish, Catherine A., Takahashi, Saki, Rodriguez-Barraquer, Isabel, Greenhouse, Bryan, Singh, Upinder, Wang, Taia T., Jagannathan, Prasanna |
| Zdroj: |
Cell Reports Medicine; 20220101, Issue: Preprints |
| Abstrakt: |
SARS-CoV-2-specific CD4+T cells are likely important in immunity against COVID-19, but our understanding of CD4+longitudinal dynamics following infection, and specific features that correlate with the maintenance of neutralizing antibodies, remains limited. Here, we characterize SARS-CoV-2-specific CD4+T cells in a longitudinal cohort of 109 COVID-19 outpatients enrolled during acute infection. The quality of the SARS-CoV-2-specific CD4+response shifts from cells producing IFNγ to TNFα from five days to four months post-enrollment, with IFNγ-IL21-TNFα+CD4+T cells the predominant population detected at later timepoints. Greater percentages of IFNγ-IL21-TNFα+CD4+T cells on day 28 correlate with SARS-CoV-2 neutralizing antibodies measured seven months post-infection (⍴=0.4, P=0.01). mRNA vaccination following SARS-CoV-2 infection boosts both IFNγ and TNFα producing, spike protein-specific CD4+T cells. These data suggest that SARS-CoV-2-specific, TNFα-producing CD4+T cells may play an important role in antibody maintenance following COVID-19. |
| Databáze: |
Supplemental Index |
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