| Autor: |
O’Dowd, Hardwin, Manske, Jenna L., Freedman, Seth A., Cochran, John E. |
| Zdroj: |
Organic Letters; May 2022, Vol. 24 Issue: 18 p3431-3434, 4p |
| Abstrakt: |
The desymmetrization of a prochiral 6-oxaspiro[3.3]heptane-2-carboxylic acid derivative via biocatalytic ketoreductase-mediated reduction has provided access to both enantiomers in high ee. The axially chiral alcohol was converted to the corresponding ester alcohol, amino acid, and amino alcohol building blocks while high enantiopurity was maintained. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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