| Autor: |
Sussman, Eric M., Shi, Huiyu, Turner, Paul A., Saylor, David M., Weaver, Jason D., Simon, David D., Takmakov, Pavel, Sivan, Shiril, Shin, Hainsworth Y., Di Prima, Matthew A., Godar, Dianne E. |
| Zdroj: |
Shape Memory and Superelasticity; June 2022, Vol. 8 Issue: 2 p98-106, 9p |
| Abstrakt: |
Nitinol is a nickel–titanium alloy widely used in medical devices for its unique pseudoelastic and shape-memory properties. However, nitinol can release potentially hazardous amounts of nickel, depending on surface manufacturing yielding different oxide thicknesses and compositions. Furthermore, nitinol medical devices can be implanted throughout the body and exposed to extremes in pH and reactive oxygen species (ROS), but few tools exist for evaluating nickel release under such physiological conditions. Even in cardiovascular applications, where nitinol medical devices are relatively common and the blood environment is well understood, there is a lack of information on how local inflammatory conditions after implantation might affect nickel ion release. For this study, nickel release from nitinol wires of different finishes was measured in pH conditions and at ROS concentrations selected to encompass and exceed literature reports of extracellular pH and ROS. Results showed increased nickel release at levels of pH and ROS reported to be physiological, with decreasing pH and increasing concentrations of hydrogen peroxide and NaOCl/HOCl having the greatest effects. The results support the importance of considering the implantation site when designing studies to predict nickel release from nitinol and underscore the value of understanding the chemical milieu at the device–tissue interface. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink