| Autor: |
McGinniss, Mary H., Binder, Richard A., Kales, Arthur N., Davey, Richard J. |
| Zdroj: |
Immunohematology; January 1987, Vol. 3 Issue: 2 p17-20, 4p |
| Abstrakt: |
A 65-year-old woman was found to have severe autoimmune hemolytic anemia. The patient was group A1Rh0(D) positive. The direct antiglobulin test was strongly positive with anti-C3 and negative with anti- IgG. The serum contained two distinct IgM antibodies, auto-anti-I and auto-anti-AI. Both were reactive at 22 °C. However, the anti-AI also was reactive in saline and in albumin at 37°C. An eluate revealed anti-AI and a weak anti-L Sequential 5’Chromium survival studies were done with group OI and Al red cells. The group OI red cells survived normally (97% at 24 hours) while the group A J red cells were removed in a “two- component” pattern characteristic of IgM complementfixing antibodies (62% survival at one hour, 49% at 24 hours). Based on these observations, the patient was subsequently transfused without incidence with six group O units of washed red cells prior to splenectomy. Although auto-anti-AI has been previously reported, this is the first case to demonstrate the use of 51Cr survival studies to determine its clinical significance. |
| Databáze: |
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