| Autor: |
Kačar, Dina, Schleissner, Carmen, Cañedo, Librada M., Rodríguez, Pilar, de la Calle, Fernando, Cuevas, Carmen, Galán, Beatriz, García, José Luis |
| Zdroj: |
Metabolic Engineering Communications; June 2022, Vol. 14 Issue: 1 |
| Abstrakt: |
Pederin is a potent polyketide toxin that causes severe skin lesions in humans after contact with insects of genus Paederus.Due to its potent anticancer activities, pederin family compounds have raised the interest of pharmaceutical industry. Despite the extensive studies on the cluster of biosynthetic genes responsible for the production of pederin, it has not yet been possible to isolate and cultivate its bacterial endosymbiont producer. However, the marine bacterium Labrenziasp. PHM005 was recently reported to produce labrenzin, the closest pederin analog. By cloning a synthetic pedOgene encoding one of the three O-methyltraferase of the pederin cluster into Labrenziasp. PHM005 we have been able to produce pederin for the first time by fermentation in the new recombinant strain. |
| Databáze: |
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