| Autor: |
Amraee, A., Khoei, S., Bahreyni-Toossi, M. T., Azimian, H., Ansari, F., Fallahi, F., Robatmili, N., Teshnizi, S. H., Darvish, L. |
| Zdroj: |
Clinical and Translational Imaging; 20220101, Issue: Preprints p1-9, 9p |
| Abstrakt: |
Background: The application of nanotechnology in the molecular diagnosis and treatment of cancer is now of paramount importance due to its practical method. In this study, we investigated the effect of ultra-small superparamagnetic iron oxide (USPIO) as T1-weighted MR images on cancer diagnosis. Methods: In this meta-analysis, a comprehensive search by two independent reviewers was performed to select initial studies. Electronic databases following: Web of Science, Google Scholar, Scopus, PubMed, Elsevier, Embase, ProQuest, and Persian databases such as Iranmedex, Magiran, and SID were searched. All searches were restricted to the English language between 2004 and 2021. A random-effect meta-analysis is used to estimate pooled effect size across initial studies. A Funnel plot with Egger’s test is used to assess potential publication bias. Results: Totally, 19 articles were included in the meta-analysis. The results of this meta-analysis showed that the optimum size of 3.71 (95% CI 3.26–4.16, p?<?0.001) on average for ultra-small iron oxide nanoparticles as a positive contrast agent in MRI T1weighted. The pooled mean r2/r1for 22 studies included in the meta-analysis was estimated at 4.53 (95% CI 3.67–5.38.16; I2?=?98.9, p?<?0.001). There was no possibility of publication bias among studies (p?>?0.05). Conclusion: The iron oxide nanoparticles with sizes below 5 nm can be used as a positive contrast agent in MRI; as shown in studies, it can be more effective than gadolinium-based contrast agents in coronary arteries or the peripheral arteries of the tumor tissue. |
| Databáze: |
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