| Autor: |
Rashid, Muhammed, Chandran, Viji Pulikkel, Nair, Sreedharan, Muthu, Deepa Sudalai, Pappuraj, Jemima, Jacob, Krupa Ann, Sridhar, Balaji, Mark, Karen, Hyder, Shabnam, Khan, Sohil, Thunga, Girish |
| Zdroj: |
Current Reviews in Clinical and Experimental Pharmacology; 2022, Vol. 17 Issue: 3 p192-204, 13p |
| Abstrakt: |
Background: Treatment with N-Acetyl Cysteine (NAC) in rodenticide poisoning has notbeen well established due to mixed study results and insufficient evidence. This review aimed tosummarize the clinical benefits of NAC in the management of rodenticide poisoning. Methods: This review follows the PICOS framework and the PRISMA guidelines. Pub-Med/MEDLINE, Scopus, and the Cochrane library were searched to identify the published literaturefrom inception to September 2020, and a reference search was performed for additional relevant studies.The English language studies addressing the use of NAC in rodenticide poisoning were consideredfor the review. We considered all experimental and observational studies due to the insufficient numberof interventional studies. Results: Ten studies (two RCTs, four observational, and four descriptive) out of 2,178 studies with492 participants were considered for the review. Only six studies (two RCTs, one prospective, andthree retrospective studies) reported recovery and mortality. Pooled results of RCTs (n=2) showed asignificant recovery rate (Odds Ratio [OR]: 3.97; 95% Confidence Interval [CI]:1.69-9.30), whereassummary estimates of prospective and retrospective studies recorded a non-significant effect. Metaanalysisof RCTs (OR: 0.25; 95% CI: 0.11-0.59; n=2) and retrospective studies (OR: 0.34; 95% CI:0.15-0.78; n=3) showed a significant reduction in mortality, whereas pooled analysis of prospectivestudies recorded a non-significant effect. A significant reduction in intubation or ventilation (OR:0.25; 95% CI: 0.11-0.60; 2 RCTs) and a non-significant (P=0.41) difference in duration of hospitalizationwas observed with NAC when compared to the non-NAC treated group. The quality of the includedstudies appeared to be moderate to high. Conclusion: Our findings indicate that NAC showed better survival and lower mortality rate whencompared to non-NAC treated group; hence NAC can be considered for the management of rodenticidepoisoning. |
| Databáze: |
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