| Abstrakt: |
Background: In the present scenario, diabetes is a growing health challenge, and its occurrenceis growing across the globe. Diabetes, with its complications like diabetic wounds, vasculopathy,neuropathy, wound infections, and oxidative stress, is a serious cause of mortality worldwide. Introduction: Among the various complications, treatment of diabetic foot and ulcers is one of themajor concerns in patients who are suffering from diabetes. The causative factors for this conditioninclude increased oxidative stress, high blood glucose levels, vascular insufficiency, and microbialinfections, and many a time, if left untreated, it may even lead to amputations of the lower extremities.The present therapy for the treatment of diabetic wounds mainly involves the use of syntheticmoieties and other biotechnology-derived biomolecules, including growth factors. Few plant productsare also useful in the treatment of wounds. Methods: Essential oils derived from various herbs are reported to possess significant wound healingpotential and promote blood clotting, help to fight infections, and accelerate the wound healingprocess. Hence, the present review is a systematic analysis of all the available data on the use ofthe natural oils with their biological source, active phytochemical constituents present, and theprobable mechanism of action for the treatment of chronic and diabetic wounds in suitable animalmodels. A methodical collection of data was performed, and information was searched up to April2020 in entirety. Key phrases used for the data search include the pathophysiology of wounds, diabeticfoot wound and its complications, natural oils for chronic and diabetic wound treatment. Results: This review summarizes the natural oils which are reported in the literature to be beneficialin the treatment of chronic wounds, while some oils have been specifically also studied againstwounds in diabetic rats. Essential oils are said to interact with the body pharmacologically, physiologicallyand psychologically and help in rapid wound healing. However, the majority of the literaturestudies have demonstrated wound healing activity only in animal models (preclinical data),and further clinical studies are necessary. Conclusion: This review provides a platform for further studies on the effective utilization of naturaloils in the treatment of chronic and diabetic wounds, especially if oils are to receive credibilityin the management of chronic wounds. |
