Bactericidal Activity of Octenidine to Various Genospecies of Borrelia burgdorferi, Sensu Lato Spirochetes in Vitroand in Vivo

Autor: TYLEWSKA-WIERZBANOWSKA, STANISŁAWA, ROGUSKA, URSZULA, LEWANDOWSKA, GRAŻYNA, CHMIELEWSKI, TOMASZ
Zdroj: Polish Journal of Microbiology; January 2017, Vol. 66 Issue: 2 p259-263, 5p
Abstrakt: The aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against Borrelia burgdorferiin suspension (in vitro) and in cell line cultures (in vivo). In the suspension method, 0.01% octenidine at 20°C and 35°C was bactericidal to Borrelia afzeli; Borrelia garini, B. burgdorferisensu stricto after 5 minutes treatment. Increase of the temperature to 35°C speed up the bactericidal effect to 1 minute. The bactericidal action of octenidine towards B. burgdorferispirochetes growing in fibroblasts was less effective and needed a longer time to kill them than in the suspension.
Databáze: Supplemental Index