| Autor: |
Arndt, Carl, Hubault, Béatrice, Hayate, Fabien, Barbe, Coralie, Afriat, Mickaël, Gillery, Philippe, Ramont, Laurent, Henry, Adrien, Boulagnon-Rombi, Camille |
| Zdroj: |
Eye; 20220101, Issue: Preprints p1-6, 6p |
| Abstrakt: |
Purpose: Altered glucose metabolism, along with low-grade inflammation, has been proposed to be involved in retinal detachment (RD)-induced cone loss. Here, we assessed intravitreal glucose and cytological profile in patients with macula-off RD. Methods: Glucose concentration was analysed in vitreous samples from 137 non-diabetic patients undergoing vitrectomy for either primary macula-off RD (n= 73) or epiretinal membrane (ERM; n= 64). Cellularity was assessed in vitreous cytospin preparations by a semi-quantitative immunostaining approach. Results: Intravitreal glucose concentration was higher in the RD group (2.28 mmol.L-1 n=73 vs 1.6 mmol.L-1 n= 64; p< 0.0001). Overall cellularity and density of macrophages were significantly higher in the vitreous of RD patients (respectively p= 0.003 and p< 0.0001). Among the RD patients, intravitreal glucose concentration correlated with macrophages density (p= 0.002): its levels remained significantly higher in eyes in which macrophages were innumerable compared to lower macrophages densities RD eyes (p= 0.0095). Conclusions: We observed a strong relationship between intravitreal glucose concentration and vitreous macrophage density. Additional indicators for vitreous glycation and low-grade inflammation should be further studied. |
| Databáze: |
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