| Autor: |
Vio, Carlos P., Olavarria, Fernando, Krause, Sergio, Herrmann, Fernando, Grob, Karin |
| Zdroj: |
Biology of the Neonate; January 1987, Vol. 52 Issue: 3 p121-126, 6p |
| Abstrakt: |
Kallikrein excretion and renal function were studied on 37 one-day-old newborn infants (14 fullterm and 23 preterm infants). Preterm infants excreted less kallikrein (p < 0.001), had lower creatinine clearance (p < 0.02) and urinary osmolality (p < 0.01). They had higher values on urinary volume (p < 0.001), FENa (p < 0.001), FEK (p < 0.02), and free water clearance (p < 0.01) than fullterm infants. The excretion of kallikrein correlated directly with gestational age (p < 0.01) and body weight (p < 0.01). No correlations were found with FENa, urinary volume, FEK or free water clearance. The values of kallikrein excretion were very low when compared with a young adult population. As kallikrein is synthesized in the distal nephron we advance as an hypothesis that the low levels of kallikrein excretion observed in newborns could be a reflection of immature distal tubular mass, and to the relative unresponsiveness of the distal nephron to hormones known to stimulate renal kallikrein such as aldosterone and antidiuretic hormone. |
| Databáze: |
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