Effects of Maternal Ethanol Ingestion on the Uptake of Alpha-Aminoisobutyric Acid by Fetal Rat Liver, Lung and Brain

Autor: Snyder, Ann K., Singh, Sant P., Pullen, Gordon L., Eman, Svetlana
Zdroj: Biology of the Neonate; January 1989, Vol. 56 Issue: 5 p277-282, 6p
Abstrakt: Maternal ethanol ingestion reduced the uptake of [14C]-α-aminoisobutyric acid (AIB) by placenta and fetal liver, lung and brain when compared with pair-fed or ad libitum-fed controls. The ratios between fetal tissue and plasma radioactivities indicated reduced AIB transport into the tissues of the ethanol-fed fetuses. Organ weights correlated with the fetal:maternal plasma 14C ratio, an indicator of the rate of placental AIB transfer, and with the tissue AIB uptake. These observations suggest that ethanol-induced growth retardation may reflect reduced nutrient availability resulting from impaired transport processes.
Databáze: Supplemental Index