| Autor: |
Brans, Yves W., Kazzi, Nadya J., Andrew, Donna S., Schwartz, Connie A., Carey, K.D. |
| Zdroj: |
Biology of the Neonate; January 1990, Vol. 58 Issue: 3 p137-144, 8p |
| Abstrakt: |
Total body water was estimated simultaneously by dilution of antipyrine (antipyrine space; APS) and H218O (18O-space; 18OS) in 5 baboon neonates and 2 two-month-old lambs (total of 14 studies). Calculations of 18OS were made either from a single plasma δ18O measured 4 h after injection of the marker (18OS4) or by extrapolation to time zero of several plasma δ18O obtained at precisely timed interval (18OS₀). Mean ( ± SD) 18OS4 was on the average 23% lower than mean 18OS₀ (796 ± 70 ml/kg vs. 650 ± 67 ml/kg, p < 0.001). Mean APS was not statistically different from mean 18OS₀ (664 ± 127 ml/kg vs. 658 ± 57 ml/kg), but APS ranged from 41 % lower to 30% higher than 18OS₀ These data and information from the literature suggest that antipyrine is of doubtful reliability and should be abandoned as a marker for total body water. |
| Databáze: |
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