CD26 and CD31 Surface Antigen Expression on Human Colostral T Cells

Autor: Bertotto, A., Spinozzi, F., Gerli, R., Castellucci, G., Bassotti, G., Crupi, S., Fabietti, G.M., Vagliasindi, C., Forenza, N., Pazzelli, P., Bartolucci, M., Vaccaro, R.
Zdroj: Biology of the Neonate; January 1995, Vol. 68 Issue: 4 p259-263, 5p
Abstrakt: The expression levels of CD26 and CD31 surface antigens, two adhesion/activation molecules with helper and suppressor activities, respectively, were found to be significantly higher on human colostral T cells (CD3+) than in autologous peripheral blood samples. These findings provide further phenotypical evidence that immune system T lymphocytes are compartmentalized in the mammary gland late in pregnancy and during lactation. The question of whether these overexpanded T lymphocyte populations in breast milk modulate in situ, either by enhancing or suppressing, the cellular and/or humoral immune response of the suckling infant remains to be answered. Additional studies are, therefore, needed to explore this intriguing field concerning the immunology of the colostrum.
Databáze: Supplemental Index