| Abstrakt: |
Synovial fluids drawn from joints of patients suffering from rheumatoid arthritis were investigated for their concentrations of proteins and activation markers of the complement, coagulation and fibrinolytic systems. A broad spectrum of plasmatic inhibitors and other hemostatic proteins were detectable by immunologic assays. Compared to normal plasma concentration ranges, levels of α2-antiplasmin, antithrombin III, heparin-cofactor II, factor H, α2-macroglobulin, inter-α-trypsin inhibitor, fibrinogen and particularly high molecular weight kininogen were found to be decreased when corrected for total protein content. However, highly elevated levels of C-reactive protein, factor XIII, PMN-elastase, prothrombin fragment F1+2 thrombin-antithrombin III, plasmin-antiplas-min and terminal complement-complexes as well as C5a were determined. Eight and 24 hours after induction of chemical synoviorthesis, a general increase in most of the parameters was observed. Statistically significant alterations were found for C1-inhibitor, factor H, α1-antitrypsin, inter-α-trypsin inhibitor, factor XIII, protein C, thrombin-antithrombin III complexes and C5a. |
