| Autor: |
Marongiu, F., Mulas, G., Mamusa, A.M., Mameli, G., Marassi, Giua, Tronci, M.B., Cambuli, A.B., Acca, M.R., Balestrieri, A. |
| Zdroj: |
Haemostasis; January 1987, Vol. 17 Issue: 5 p301-304, 4p |
| Abstrakt: |
In order to investigate whether α2-antiplasmin (α2-AP) levels may be related to thrombin activity, we measured α2-AP and fibrinopeptide A (FPA) in 51 patients with clinical conditions frequently associated with increased thrombin activity. The diagnoses were: atherosclerotic disease, chronic inflammatory disease and hematological neoplastic disease. A significant negative correlation was found between α2-AP and FPA (p < 0.01). When patients were divided into three subgroups on the basis of their FPA levels, a significant reduction in α2-AP was found in patients with the highest FPA concentration ( > 9 ng/ml). Accordingly, a significant negative relationship between α2-AP and FPA was found only in this subgroup (p < 0.01). Our data suggest that the partial consumption of α2-AP in patients with elevated FPA levels may reflect a subclinical fibrinolysis activation secondary to increased thrombin activity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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