| Autor: |
Almeida Jr, Hiram Larangeira de, Almeida, Antônia Larangeira de, Martinez, Pedro Henrique Evangelista, Boff, Ana Letícia |
| Zdroj: |
Anais Brasileiros de Dermatologia; May-June 2022, Vol. 97 Issue: 3 p376-378, 3p |
| Abstrakt: |
A 73-year-old male patient developed a poorly differentiated squamous cell carcinoma in the anal canal nine months ago. He was treated with two cycles of 5-fluorouracil and cisplatin and concomitant radiotherapy (6 MeV linear photon accelerator, total dose of 54 Gy), with complete remission. Since forty-five days he presentes a painful perianal and intergluteal erosion with circinate pustular borders. Light microscopy showed pseudoepitheliomatous hyperplasia of the epidermis with microabscesses of inflammatory cells (neutrophils and eosinophils) and acantholytic keratinocytes . Indirect immunofluorescence was positive for IgG, with an intercellular pattern, 1:80 titer. The diagnosis of radiotherapy-induced pemphigus vegetans was established and there was significant regression with oral prednisone (40 mg) and topical betamethasone. |
| Databáze: |
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