| Autor: |
Fang, Mougui, Wu, Pingjie, Wang, Xia, Xie, Ziyue, Hou, Yali, Liu, Yao, Wu, Jingjing, Wu, Fanhong |
| Zdroj: |
The Journal of Organic Chemistry; March 2022, Vol. 87 Issue: 6 p4107-4111, 5p |
| Abstrakt: |
A novel asymmetric copper-catalyzed intermolecular cyanobenzoyldifluoromethylation of alkenes with iododifluoromethyl ketones and TMSCN has been reported, which provides a particularly valuable route to access chiral β-difluoroacyl nitriles with excellent enantioselectivities. The method permits the efficient cyanation of varied β-difluoroacyl-benzylic radicals in mild conditions with high functional group tolerance. The reaction proceeds through a radical pathway. In order to get insight into the stereochemical outcome, computational mechanistic studies were conducted. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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