| Autor: |
Sander, Maike, Sussel, Lori, Conners, Jennifer, Scheel, David, Kalamaras, Julie, Cruz, Filemon Dela, Schwitzgebel, Valerie, Hayes-Jordan, Andrea, German, Michael |
| Zdroj: |
Development; December 2000, Vol. 127 Issue: 24 p5533-5540, 8p |
| Abstrakt: |
Most insulin-producing β-cells in the fetal mouse pancreas arise during the secondary transition, a wave of differentiation starting at embryonic day 13. Here, we show that disruption of homeobox gene Nkx6.1 in mice leads to loss of β-cell precursors and blocks β-cell neogenesis specifically during the secondary transition. In contrast, islet development in Nkx6.1/Nkx2.2 double mutant embryos is identical to Nkx2.2 single mutant islet development: β-cell precursors survive but fail to differentiate into β-cells throughout development. Together, these experiments reveal two independently controlled pathways for β-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of β-cell differentiation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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