| Autor: |
Simcox, Amanda A., Roberts, Ian J. H., Hersperger, Evelyn, Gribbin, M. Clare, Shearn, Allen, Whittle, J. Robert S. |
| Zdroj: |
Development; December 1989, Vol. 107 Issue: 4 p715-722, 8p |
| Abstrakt: |
Drosophila embryos homozygous for strong mutations in each of the segment-polarity genes wingless (wg), engrailed (en), naked (nkd) and patched (ptc) form a larval cuticle in which there is a deletion in every segment. The mutant embryos normally fail to hatch but by in vivo culture we were able to show which could produce adult structures. Cultured wg− embryos did not produce any adult structures. Cultured en− embryos produced eye-antennal derivatives and rarely produced partial thoracic structures. nkd− and ptc− embryos produced eye-antennal and thoracic derivatives. The nkd− and ptc− thoracic imaginal discs developed with an abnormal morphology and abnormal pattern of en-expression. Our findings are consistent with the idea that the thoracic imaginal discs derive from two adjacent groups of cells that express wg and en respectively in the embryo. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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