| Autor: |
Tang, Xuejiao, Liu, Kun, Qu, Zeming, Zhan, Junyan, Zhu, Rukui, Teng, Fan, Meng, Lili, Huang, Yanmin, Huang, Chusheng, He, Yimiao, Zhu, Qiang |
| Zdroj: |
Chinese Chemical Letters; 20220101, Issue: Preprints |
| Abstrakt: |
A [3 + 2]/[2 + 1] cycloaddition reaction of gem‑difluorocyclopropenes is presented, offering a mild and efficient approach to accessing tri- and tetra-substituted 4-fluoropyridines in moderate to good yields with excellent regioselectivity. Multiple synthetic applications, including process-scale reactions, modification of bioactive molecules, derivatization reactions and synthesis of the analogue of the PKM2 modulator, are subsequently described. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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