| Autor: |
Shilling, Hannah S, Garland, Suzanne M, Costa, Anna-Maria, Marceglia, Alex, Fethers, Katherine, Danielewski, Jennifer, Murray, Gerald, Bradshaw, Catriona, Vodstrcil, Lenka, Hocking, Jane S, Kaldor, John, Guy, Rebecca, Machalek, Dorothy A |
| Zdroj: |
Sexually Transmitted Infections; 2022, Vol. 98 Issue: 2 p115-120, 6p |
| Abstrakt: |
BackgroundRisk of pelvic inflammatory disease associated with Chlamydia trachomatisand Mycoplasma genitaliumis increased after termination of pregnancy (TOP) and may be increased after insertion of intrauterine devices (IUDs). Screening prior to these procedures is recommended only for C. trachomatis. We examined C. trachomatisand M. genitaliumprevalence and associated factors among women presenting to a pregnancy termination and contraception service over 10 years.MethodsRetrospective analysis of clinical data collected from 17 573 women aged 15–45 years in 2009–2019 and for 266 M. genitaliumpositive women tested for macrolide resistance-associated mutations in 2016–2019.ResultsC. trachomatisand M. genitaliumprevalence was 3.7% and 3.4%, respectively. In multivariable analyses, shared risk factors were younger age (p<0.001, for both C. trachomatisand M. genitalium), socioeconomic disadvantage (p=0.045 and p=0.008, respectively) and coinfection (p<0.001, for both sexually transmitted infections), with 10.1% of C. trachomatispositive women also positive for M. genitalium. Additional risk factors were earlier year of visit (p=0.001) for C. trachomatisand for M. genitaliumresiding outside a major city (p=0.013). The proportion of M. genitaliuminfections tested between 2016 and 2019 with macrolide resistance-associated mutations was 32.7%.ConclusionsGiven the high level of antimicrobial resistance and the prevalence of coinfection, testing C. trachomatispositive women for M. genitaliumcould be considered in this setting to prevent further spread of resistant infections. Further research is required into the causal link between M. genitaliumand pelvic inflammatory disease in women undergoing TOP and IUD insertion. |
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