| Autor: |
Barcelos Valiatti, Tiago, Silva Carvalho, Tatiane, Fernandes Santos, Fernanda, Silva Nodari, Carolina, Cayô, Rodrigo, da Silva, Juliana Thalita Paulino, da Silva, Cicileia Correia, Ferreira, Jacqueline Andrade, Moura, Lorena Brandhuber, dos Santos, Levy Assis, Gales, Ana Cristina |
| Zdroj: |
Brazilian Journal of Microbiology; June 2022, Vol. 53 Issue: 2 p795-799, 5p |
| Abstrakt: |
In Brazil, carbapenem-resistant A. baumannii(CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumanniiisolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried blaOXA-23and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory. |
| Databáze: |
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