| Autor: |
Zoubir, Jallal, Bougdour, Nadia, Radaa, Chaimae, Idlahcen, Abderrahim, Bakas, Idriss, Assabbane, Ali |
| Zdroj: |
Sensors International; January 2022, Vol. 3 Issue: 1 |
| Abstrakt: |
Metronidazole (MTZ) is a widely used antibiotic to treat infections caused by anaerobic bacteria, protozoa, and bacteroids such as trichromonosis and vaginosis. In this study, we present a simple strategy for constructing an electroanalysis platform for metronidazole in real samples. We prepared a modified carbon paste with α-Fe2O3magnetic core nanoparticles to construct an α-Fe2O3@CPE electrochemical sensor. The surface morphology and composition of the sensor were evaluated using several methods, such as X-ray diffraction and scanning electron microscope. The average size of the α-Fe2O3magnetic core nanoparticles was around 34.30 nm. Cyclic voltammetry, electrochemical impedance spectroscopy and chrono-coulometry were performed for the understanding of the electron transfer behavior on the electrocatalytic surface of α-Fe2O3@CPE and the unmodified electrode CPE. The resulting sensor demonstrates a very good shift of the Metronidazole reduction peak to a more positive potential (−0.57v vs Ag/AgCl) compared to the unmodified CPE electrode (−0.71v .vs Ag/AgCl). The Metronidazole peak reduction current Ipc varies linearly with metronidazole concentration in the range of 10-4 M to 0.8x10-6 M with a limit of detection and limit of quantification of 2.852x10-7 M and 9.509x10-7 M respectively. Exceeding the detection limits of several existing analytical methods. The proposed procedure has been successfully demonstrated on pharmaceutical tablets and real tap water and urine samples. |
| Databáze: |
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