| Autor: |
Gwon, Yunyeong, Lee, Minhan, Kim, Dongwook, Chang, Sukbok |
| Zdroj: |
Organic Letters; February 2022, Vol. 24 Issue: 4 p1088-1093, 6p |
| Abstrakt: |
Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst. The α-amidation was facile for both α-aryl and α-alkyl esters. Density functional theory studies revealed that the generation of a putative Ir-nitrenoid is facilitated by the chelation of the countercation additive during the N–O bond cleavage of the nitrene precursor. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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