| Autor: |
Fiore, Cecilia, Baraghini, Alessandra, Shemchuk, Oleksii, Sambri, Vittorio, Morotti, Manuela, Grepioni, Fabrizia, Braga, Dario |
| Zdroj: |
Crystal Growth & Design; February 2022, Vol. 22 Issue: 2 p1467-1475, 9p |
| Abstrakt: |
Three structurally similar antibiotics of the cephalosporin (CEPH) class, namely, cephalexin (CPX), cephradine (CFD), and cefaclor (CFC), have been co-crystallized with thymol (THY) via different preparation techniques, yielding the hydrated co-crystals CPX·THY·2.5H2O form I and form II, CFD·THY·2.5H2O, and CFC·THY·4H2O. All co-crystals were structurally characterized by single crystal and/or powder X-ray diffraction. In all co-crystals, except in the case of the elusive metastable form I of CPX·THY·2.5H2O, the CEPH molecules interact with thymol only via water bridges; i.e., there is no direct hydrogen bonding between CEPH molecules and THY. Preliminary antimicrobial experiments via measurements of minimal inhibitory concentration (MIC) provide clear-cut evidence that the association with thymol increases the resistance of both Gram-negative and Gram-positive bacteria to the antibiotic with respect to pure CEPH as well as to physical mixtures of CEPH with thymol. |
| Databáze: |
Supplemental Index |
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