| Autor: |
Rapalli, Vamshi Krishna, Mahmood, Arisha, Waghule, Tejashree, Gorantla, Srividya, Kumar Dubey, Sunil, Alexander, Amit, Singhvi, Gautam |
| Zdroj: |
Expert Opinion on Drug Delivery; December 2021, Vol. 18 Issue: 12 p1829-1842, 14p |
| Abstrakt: |
ABSTRACTIntroductionInvestigating the transportation of a drug molecule through various layers of skin and determining the amount of drug retention in skin layers is of prime importance in transdermal and topical drug delivery. The information regarding drug permeation and retention in skin layers aids in optimizing a formulation and provides insight into the therapeutic efficacy of a formulation.Areas coveredThis perspective covers various methods that have been explored to estimate drug/therapeutics in skin layers using in vitro, ex vivo, and in vivoconditions. In vitromethods such as diffusion techniques, ex vivomethods such as isolated perfused skin models and in vivotechniques including dermato-pharmacokinetics employing tape stripping, and microdialysis are discussed. Application of all techniques at various stages of formulation development where various local and systemic effects need to be considered.Expert opinionThe void in the existing methodologies necessitates improvement in the field of dermatologic research. Standardization of protocols, experimental setups, regulatory guidelines, and further research provides information to select an alternative for human skin to perform skin permeation experiments to increase the reliability of data generated through the available techniques. There is a need to utilize multiple techniques for appropriate dermato-pharmacokinetics evaluation and formulation’s efficacy. |
| Databáze: |
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