| Autor: |
de Andrade, Letícia Kellen, Levican, Arturo, Cerdeira, Louise, de Morais, Andressa Batista Zequini, Braz, Melissa Maia, Martins, Evelin Rodrigues, Casella, Tiago, Moura, Quézia, Fuga, Bruna, Lincopan, Nilton, Nogueira, Mara Corrêa Lelles |
| Zdroj: |
Brazilian Journal of Microbiology; 20220101, Issue: Preprints p1-4, 4p |
| Abstrakt: |
Hemodialysis patients are at high risk for bloodstream infections associated with highest morbidity and mortality rates. Bacterial species not commonly related to such infections has been hardly identified by traditional methods. Pseudocitrobacteris a novel genus of the order Enterobacteralesthat is associated with carbapenemase genes and nosocomial infection. In this context, we have investigated nine cases of bloodstream infections by carbapenem-resistant Gram-negative bacilli in patients assisted at a hemodialysis unit in Brazil. The infections were caused by a metallo-β-lactamase (IMP-1)-producing clone (> 90% XbaI-PFGEsimilarity) of Pseudocitrobacter vendiensis, displaying a multidrug-resistant profile to broad-spectrum cephalosporins, carbapenems, chloramphenicol, and trimethoprim-sulfamethoxazole. S1-PFGEand Southern blot hybridization revealed that blaIMP-1was carried by a 200-kb IncC/ST3 plasmid. Patients were successfully treated with amikacin, and strict disinfection procedures and hand washing protocols were reinforced. We report the emergence of P. vendiensis, a recently described species of the genus, in bloodstream infections of patients undergoing hemodialysis. Considering the epidemic potential of carbapenemase-producing Enterobacteralesin hospital settings, surveillance of this emerging pathogen is of utmost importance. |
| Databáze: |
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