Detam1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential

Autor: Widowati, Wahyu, Prahastuti, Sijani, Hidayat, Meilinah, Hasianna, Stella Tinia, Wahyudianingsih, Roro, Eltania, The Fransiska, Azizah, Alya Mardhotillah, Aviani, Jenifer Kiem, Subangkit, Mawar, Handayani, Rr Anisa Siwianti, Kusuma, Hanna Sari Widya
Zdroj: Journal of Traditional and Complementary Medicine; July 2022, Vol. 12 Issue: 4 p426-435, 10p
Abstrakt: Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean (Glycinemax L. Merr.) has been reported contain high levels of phenolics and anthocyanins that has antioxidant activity. This study aims to determine the effect of ethanol extract of black soybean (EEBS) against cisplatin-induced nephrotoxicity in rats.
Databáze: Supplemental Index