| Autor: |
Akabane-Nakata, Masaaki, Chickering, Tyler, Harp, Joel M., Schlegel, Mark K., Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah |
| Zdroj: |
Organic Letters; January 2022, Vol. 24 Issue: 2 p525-530, 6p |
| Abstrakt: |
Toward the goal of evaluation of carbocyclic ribonucleoside-containing oligonucleotide therapeutics, we developed convenient, scalable syntheses of all four carbocyclic ribonucleotide phosphoramidites and the uridine solid-support building block. Crystallographic analysis confirmed configuration and stereochemistry of these building blocks. Duplexes with carbocyclic RNA (car-RNA) modifications in one strand were less thermodynamically stable than duplexes with unmodified RNA. However, circular dichroism spectroscopy indicated that global conformations of the duplexes containing car-RNAs were similar to those in the unmodified duplexes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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