| Autor: |
Hughes, Sarah R., Buckley, Theresa L., Brain, Susan D. |
| Zdroj: |
European Journal of Pharmacology; September 1992, Vol. 219 Issue: 3-4 p481-484, 4p |
| Abstrakt: |
The capsaicin analogue olvanil stimulated an increase in cutaneous blood flow when injected intradermally into the anaesthetised rabbit, as measured using a 133Xenon clearance method. Olvanil was found to be a 10-fold more potent vasodilator (on a molar basis) than capsaicin. The effect of both vasodilators was significantly inhibited by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8–37). These findings suggest that olvanil stimulates the efferent function of cutaneous sensory nerves in a more potent manner than capsaicin. We therefore suggest that olvanil is a useful pharmacological tool for studying the activity of neuropeptides released from sensory nerves. |
| Databáze: |
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