| Autor: |
Manabe, Yoshiyuki, Matsumoto, Takuya, Ikinaga, Yuka, Tsutsui, Yuya, Sasaya, Shota, Kadonaga, Yuichiro, Konishi, Akihito, Yasuda, Makoto, Uto, Tomoya, Dai, Changhao, Yano, Kumpei, Shimoyama, Atsushi, Matsuda, Ayana, Fukase, Koichi |
| Zdroj: |
Organic Letters; January 2022, Vol. 24 Issue: 1 p6-10, 5p |
| Abstrakt: |
Catalytic glycosylations with glycosyl fluorides using BF3·Et2O are presented. Glycosylations with both armed and disarmed donors were efficiently catalyzed by 1 mol% of BF3·Et2O in a nitrogen-filled glovebox without the use of dehydrating agents. Our finding is in sharp contrast with conventional BF3·Et2O-mediated glycosylations, where excess Lewis acid and additives are required. Mechanistic studies indicated that the chemical species formed by the reaction of in situgenerated HF and glass vessels are involved in the catalytic cycle. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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