| Autor: |
Wei, Xia, Su, Jun-Cheng, Hu, Jin-Shan, He, Xi-Xin, Lin, Shuang-Jun, Zhang, Dong-Mei, Ye, Wen-Cai, Chen, Min-Feng, Lin, Hou-Wen, Zhang, Cui-Xian |
| Zdroj: |
Organic Letters; January 2022, Vol. 24 Issue: 1 p158-163, 6p |
| Abstrakt: |
Comprehensive analyses of the metabolite spectra of Aspergillussp. EGF 15-0-3 under different culture conditions revealed the presence of unique environmental-induced metabolites exclusively from the rice medium. Subsequent target isolation afforded four unprecedented indole diketopiperazine-based hybrids with a pyrano[3′,2′:7,8]isochromeno[4,3-b]pyrazino[2,1-i]indole core (1and 2) or a spiro[piperazine-2,2′-pyrano[3,4,5-de]chromene] scaffold (3and 4). Putative biosynthetic pathways for 1–4, with Diels–Alder cycloadditions as key steps, were proposed. 1–4exhibited selective cytotoxicities among several human cancer cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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