| Autor: |
Hassani, Seyed A., Lendor, Sofia, Neumann, Adam, Roy, Kanchan Sinha, Boroujeni, Kianoush Banaie, Hoffman, Kari L., Pawliszyn, Janusz, Womelsdorf, Thilo |
| Zdroj: |
Biological Psychiatry Global Open Science; 20210101, Issue: Preprints |
| Abstrakt: |
Donepezil exerts pro-cognitive effects by non-selectively enhancing acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro-cognitive effects of attentional control and cognitive flexibility are the prefrontal cortex and the anterior striatum which have different pharmacokinetic sensitivities to ACh modulation. We speculated that these area-specific ACh profiles lead to distinct optimal dose-ranges for donepezil to enhance the cognitive domains of attention and flexible learning. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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