| Autor: |
Tantanavipas, Siriluk, Aojanepong, Tepchongchit, Waiyaput, Wanwisa, Sophonsritsuk, Areepan |
| Zdroj: |
Journal of Endometriosis and Pelvic Pain Disorders; December 2021, Vol. 13 Issue: 4 p250-255, 6p |
| Abstrakt: |
Introduction: Both autophagy and apoptosis play a role in the cyclic remodeling of the endometrium. The abnormal regulation of genes and signaling pathways in the eutopic endometrium plays a role in the abnormal migration and implantation in adenomyosis.Objective: The present study investigates the mRNA expression of autophagy and apoptosis-related genes BECN1, LC3B, and BCL2in the eutopic endometrium of patients with adenomyosis compared with healthy premenopausal women.Materials and methods: The present work was a cross-sectional study conducted between July 2018 and April 2019. The participants were 32 premenopausal women who attended the surgery for adenomyosis and other benign gynecological conditions. The participants were divided into two groups, with 16 women in the adenomyosis group and 16 healthy women in the control group. Endometrial tissues were collected during the proliferative menstrual phase for a quantitative real-time polymerase chain reaction.Results: The mRNA expression of BECN1, LC3B, and BCL2were normalized by geometric mean mRNA expression of actinand GAPDH. There was no significant difference in mRNA expression for all three genes when comparing the control and adenomyosis groups.Conclusions: The mRNA expressions of autophagy-related genes BECN1and LC3Band anti-apoptosis-related gene BCL2were not significantly different in the eutopic endometrium of patients with adenomyosis compared with healthy premenopausal women during the proliferative menstrual phase. |
| Databáze: |
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