| Autor: |
Kural, Alev, Khan, Imran, Seyit, Hakan, Caglar, Tuba R, Toklu, Pınar, Vural, Meltem |
| Zdroj: |
Future Microbiology; January 2022, Vol. 17 Issue: 1 p5-15, 11p |
| Abstrakt: |
Aims:Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. Methods & results:A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in Akkermansia, Alistipes, Streptococcus, Ruminococcusand Parabacteroideswas observed after LSG. Conclusion:In addition to lowering BMI, LSG remodeled gut microbiota composition. |
| Databáze: |
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