| Autor: |
Komoriya, Keiji, Tsuchimoto, Masahiro, Okamiya, Yoshiaki, Takeshita, Toru, Naruchi, Tatsuyuki, Yamamoto, Itaru |
| Zdroj: |
The Japanese journal of pharmacology; January 1983, Vol. 33 Issue: 1, Number 1 Supplement 1 p308-308, 1p |
| Abstrakt: |
Delayed type hypersensitivity (DTH) of spontaneous hypertensive rats (SHR) was compared with that of normotensive rats (WKY). Rats were sensitized with Bordetella pertussisin Freund’s complete adjuvant at 8 wk of age and challenged 12 days later. SHR showed less intensity of DTH than WKY did, especially 4 8—72 hr after challenge. Similar results were obtained in SHR sensitized at 4 wk of age, which showed slight hypertension. When allogenic thymocytes were transferred 3 times at 6 day intervals from day of sensitization, WKY thymocytes potentiated DTH in SHR. On the contrary, DTH in WKY was suppressed by the SHR thymocytes. However, the transfer of these thymocytes had no obvious effect on blood pressure. Interestingly the transfer of WKY thymocytes to SHR at 3 wk of age restored the hypertension, but not the DTH reaction. When animals were predosed for four weeks, prior sensitization and dosing was finished at day of challenge, levamisole (5 mg/kg, p.o.) showed potentiating effect on DTH in SHR, but not on hypertension. D-Penicillamine (25 mg/kg, p.o.), however, had no effect on both DTH and blood pressure. These results suggest that SHR might have an increase of suppressor cell and/or decrease of helper cell in DTH. The relationship between DTH and hypertension should be investigated further. |
| Databáze: |
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