Continuous live cell imaging analysis reveals a subtle pathological alteration with cell behaviors in congenital heart malformation

Autor: Li, Xin, Yue, Yanzhu, Zhang, Youdong, Liao, Yuanhui, Wang, Qianhao, Bian, Yunkun, Na, Jie, He, Aibin
Zdroj: Fundamental Research; 20210101, Issue: Preprints
Abstrakt: •For the first time, we visualized the whole mouse embryonic process of congenital heart malformation via in toto live imaging and tracing holistic lineage histories.•Specifically, we uncovered the cellular mechanisms of hypotrabeculation with both reduced proliferation of trabecular cardiomyocytes from early fate segregation and markedly impaired oriented cell division and migration.
Databáze: Supplemental Index