| Abstrakt: |
Previously, gallstone formation was observed in mice fed a diet containing 1 $ cholic acid (CA), in which the cholesterol saturation index, calculated from the lipid composition, did not change significantly, and the content of taurocholic acid (TCA) in bile increased remarkably. These results suggest that TCA plays an important role in gallstone formation. In the present study, mice were divided into 6 groups and maintained for 40 days with a diet containing 1 % CA, 1 % cheno-deoxycholic acid (CDCA), 1 °/o ursodeoxycholic acid (UDCA), 1 % deoxycholic acid (DCA), 1 cholesterol (CH) and a normal diet. Stone formation was scarcely seen except in CA given group, and no significant increase in cholesterol saturation index was detected in all groups examined. The major components of bile acids in the group given CA, CDCA, UDCA, DCA, and CH were TCA (90 %), TCDCA (66 %), TUDCA (74 %), TCA (53 #) and TDCA (28 #), and TCA (70 %), respectively. These results indicate that marked increase of TCA in bile causes the formation of gallstones, while the cholesterol saturation index is kept on a lower value. The bile containing TCA as the main element of bile acids probably shows lower capacity for cholesterol solubilization. |
