| Autor: |
Nicolaou, K. C., Pan, Saiyong, Shelke, Yogesh, Ye, Qiuji, Das, Dipendu, Rigol, Stephan |
| Zdroj: |
Journal of the American Chemical Society; December 2021, Vol. 143 Issue: 49 p20970-20979, 10p |
| Abstrakt: |
A new synthetic strategy for the total synthesis of norhalichondrin B featuring a highly convergent approach and our recently disclosed reverse approach for the synthesis of cyclic ether structural motifs is disclosed. Resulting in the shortest route to norhalichondrin B disclosed thus far, the reported total synthesis was achieved through the synthesis of two almost equally complex fragments whose coupling and short elaboration sequence featured an essential epimerization of the C16 stereocenter occurring concurrently with a simple acid-induced deprotection, a tactic based on a prior study along the synthetic route. This unprecedented strategy within the halichondrin family of natural products could find practical application to the synthesis of other more or less complex natural or designed halichondrin analogues. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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