| Autor: |
Joshi, Rashmi, Banerjee, Surya Jyoti, Curtiss, Jennifer, Ashley, Amanda K. |
| Zdroj: |
Journal of Applied Genetics; 20240101, Issue: Preprints p1-4, 4p |
| Abstrakt: |
The nonhomologous end-joining pathway is a primary DNA double-strand break repair pathway in eukaryotes. DNA ligase IV (Lig4) catalyzes the final step of DNA end ligation in this pathway. Partial loss of Lig4in mammals causes Lig4 syndrome, while complete loss is embryonically lethal. DNA ligase 4(DNAlig4) null Drosophila melanogasteris viable, but sensitive to ionizing radiation during early development. We proposed to explore if DNAlig4loss induced other long-term sensitivities and defects in D. melanogaster.We demonstrated that DNAlig4mutant strains had decreased lifespan and lower resistance to nutrient deprivation, indicating Lig4 is required for maintaining health and longevity in D. melanogaster. |
| Databáze: |
Supplemental Index |
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