No aggravation of renal injury in apolipoprotein E knockout mice (ApoE(-/-)) after subtotal nephrectomy.

Autor: Buzello, Moriz, Haas, Christian Stefan, Hauptmann, Frank, Gross, Marie Luise, Faulhaber, Jörg, Schultze-Mosgau, Stefan, Ehmke, Heimo, Ritz, Eberhard, Amann, Kerstin
Zdroj: Nephrology Dialysis Transplantation; March 2004, Vol. 19 Issue: 3 p566-573, 8p
Abstrakt: There is substantial experimental evidence that various forms of dyslipidaemia aggravate the course of renal failure and that reversal of dyslipidaemia ameliorates progression of renal failure. The apolipoprotein E knockout mouse (ApoE(-/-)) is an established model of accelerated atherogenesis. We investigated whether the course of renal disease after uninephrectomy (UNX) and subtotal nephrectomy (SNX) is altered in ApoE(-/-) mice compared with their genetic controls.
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