| Autor: |
Zucker, Roy, Gaisa, Michael, Sigel, Keith, Singer, Ilan, Adler, Amos, Turner, Dan, Ben Ami, Ronen, Nissan, Israel, Chan, Courtney, Halperin, Tamar |
| Zdroj: |
International Journal of STD & AIDS; February 2022, Vol. 33 Issue: 2 p114-122, 9p |
| Abstrakt: |
Chlamydia trachomatis(CT) and Neisseria gonorrhoeae(NG) infections are common among men who have sex with men (MSM). Many oropharyngeal and anorectal infections remain asymptomatic. We aimed to evaluate triple-site screening following PrEP introduction. We enrolled a prospective cohort study including 210 asymptomatic MSM during 2019–2020, analyzed by groups: HIV positive (HIV+), HIV−uninfected using PrEP (HIV−/PrEP+), or HIV-uninfected not using PrEP (HIV−/PrEP−). A self-administered questionnaire captured demographic information and sexual risk-taking behaviors. CT/NG testing results were compared between study groups and predictors of infection were evaluated. We included 59 HIV+, 70 HIV−/PrEP+, and 81 HIV−/PrEP− subjects. 30% (n= 62) of participants tested positive for CT/NG. HIV−/PrEP+ group had highest proportion of infections (n= 33, 47%) followed by HIV−/PrEP− (n= 16, 22%) and HIV+ (n=13, 20%; p< .001). Importantly, 98% (80/82) of pharyngeal/anorectal CT/NG infections were missed in genitourinary tract screening alone. PrEP use and previous syphilis infection were the strongest risk factor for CT/NG. Extra-genital asymptomatic CT/NG infections were prevalent among MSM. These data highlight the importance of routine extra-genital CT/NG testing in asymptomatic sexually active MSM. The study describes the consequences for three-site testing lack of implementation in the PrEP era. |
| Databáze: |
Supplemental Index |
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